Endocrine Abstracts

MicroRNAs (miRNA) are small (18–24 nts) non-coding RNAs which are part of an evolutionarily highly conserved intracellular mechanism to regulate gene expression in a sequence-specific manner. These regulatory RNAs function by acting as sequence-specific guides which recruit multi-protein complexes to target mRNA sequences which are subsequently silenced. miRNAs are processed from primary transcripts (pri-miRNA) by cellular components which are also at least partially invo...